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Conclusion: The classification criteria allow identifying centralsensitization pain following cancer treatment.
2
Capsaicin was applied on both forearms of ten healthy volunteers to induce peripheral and centralsensitization.
3
Animal studies indicate that glutamate plays a key role in pain transmission, centralsensitization, and cortical spreading depression.
4
The N-methyl-D-aspartate receptor (NMDAR) contributes to centralsensitization in the spinal cord and the generation of pain hypersensitivity.
5
The NMDAR-mediated astrocyte-to-neuron signalling thus represents a novel pathway that may contribute to the control of centralsensitization in pathological pain.
1
Recently, the Central Sensitization Inventory (CSI) was developed to assess symptoms of CS and centralsensitivitysyndromes.